Effect of Schistosoma mansoni infection on innate and HIV-1 specific T cell immune responses in HIV-1 infected Ugandan fisher folk

Publication Date: 
Wednesday, February 10, 2016
Obuku AE, Asiki G, Abaasa A, Ssonko I, Harari A, van Dam GJ, Corstjens PL, Joloba M, Ding S, Mpendo J, Nielsen L, Kamali A, Elliott AM,Pantaleo G, Kaleebu P, Pala P

In Uganda, fisher folk have HIV prevalence rates about 4 times higher than the national average and are often co-infected with S. mansoni. We hypothesized that innate immune responses and HIV specific Th1 immune responses might be downmodulated in HIV/S. mansoni co-infected individuals compared to HIV+ /S. mansoni negative individuals. We stimulated whole blood with innate receptor agonists and analysed supernatant cytokines by Luminex. We evaluated HIV-specific responses by intracellular cytokine staining for IFN-γ, IL-2 and TNF-α. We found that the plasma viral load and CD4 count was similar between the HIV+SM+ and HIV+SM- individuals. In addition, the TNF-α response to the imidazolequinoline compound CL097 and β-1, 3-glucan curdlan, was significantly higher in HIV/S. mansoni co-infected individuals compared to HIV only infected individuals. The frequency of HIV specific IFN-γ+IL-2-TNF-α- CD8 T cells and IFN-γ+IL-2-TNF-α+ CD4 T-cells was significantly higher in HIV/S. mansoni co-infected individuals compared to HIV only infected individuals. These findings do not support the hypothesis that S. mansoni down-modulates innate or HIV specific Th1 responses in HIV/S. mansoni co-infected individuals.

Publisher: 
AIDS Res Hum Retroviruses